|
KMID : 0043320220450080558
|
|
Archives of Pharmacal Research
2022 Volume.45 No. 8 p.558 ~ p.571
|
|
|
Protection of the hematopoietic system against radiation-induced damage: drugs, mechanisms, and developments
|
|
Wei Yuanyun
Gong Yaqi
Wei Shuang
Chen Yonglin
Cui Jian
Lin Xiang
Yu Yueqiu
Yan Hongxia
Qin Hui
Yi Lan
|
|
|
Abstract
|
|
|
|
Sometimes, people can be exposed to moderate or high doses of radiation accidentally or through the environment. Radiation can cause great harm to several systems within organisms, especially the hematopoietic system. Several types of drugs protect the hematopoietic system against radiation damage in different ways. They can be classified as “synthetic drugs” and “natural compounds.” Their cellular mechanisms to protect organisms from radiation damage include free radical-scavenging, anti-oxidation, reducing genotoxicity and apoptosis, and alleviating suppression of the bone marrow. These topics have been reviewed to provide new ideas for the development and research of drugs alleviating radiation-induced damage to the hematopoietic system.
|
|
|
KEYWORD
|
|
|
Radiation damage, Hematopoietic system, Protection, Synthetic drugs, Natural compounds
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|